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21/7/2015, · The facial nerve is composed of approximately 10,000 ,neurons,, 7,000 of which are myelinated and innervate the nerves of facial expression. Three thousand of the nerve fibers are somatosensory and secretomotor and make up the nervus intermedius. The course of the facial nerve and its central connections can be roughly divided into the segments listed in Table 1, below.
Masked facies, (hypomimia) Reduced eye blinking. Drooling. Soft voice (hypophonia) Dysphagia. Freezing. Anosmia. Sensory disturbances (e.g., pain) ... (LC), serotonin ,neurons, in the raphe nuclei of the brainstem, and ,neurons, of the olfactory system, cerebral hemispheres, spinal cord, and peripheral autonomic nervous system.
lead pipe or cogwheel rigidity, and ,masked facies,. . 1. Substantia nigra (pars compacta) contains pigmented dopaminergic ,neurons, that project to the striatum; the dopamine has the general effect of facilitating movement. 2. In Parkinson's disease, >70% of dopaminergic ,neurons, in the substantia nigra die. There is also neuronal loss in other ...
Examples include parkinsonism caused by vascular injury, drugs, trauma, toxin exposure, neoplasms, infections and degenerative or hereditary conditions. Clinical features may include bradykinesia, rigidity, parkinsonian gait, and ,masked facies,. In general, tremor is less prominent in secondary parkinsonism than in the primary form.
Majority of ,neurons, in striatum are medium spiny ,neurons, (medium sized 10 -20 um in diameter). Medium aspiny ,neurons,, large spiny ,neurons, and large aspiny ,neurons, are also found in striatum. In striatum, AchE-rich zones k/a matrix are surrounded by AchE-poor zones k/a striosomes. Similar distribution is also found for Enkephalin, Substance P and Somatostatin.
Masked facies, (hypomimia) Reduced eye blinking. Soft voice (hypophonia) Dysphagia. Freezing. Anosmia: Rest tremor. Rigidity. Gait disturbance/postural instability. Sensory disturbances (e.g., pain) Mood disorders (e.g., depression) Sleep disturbances (e.g., RBD) Autonomic disturbances Orthostatic hypotension Gastrointestinal disturbances
Parkinson’s disease is characterized by the accumulation of phosphorylated alpha-synuclein within the ,neurons, in the region of the brain known as the substantia nigra, resulting in some of the characteristic features of slowness, tremor and ,masked facies,.
masked, . ,facies,), Stooped posture, Slowing of voluntary movement, Festinating gait (progressively shortened, accelerated steps), ... - And this slows the process of protofibrils to fibril conversion and the protofibrils are toxic to the ,neurons, and this may explain dopaminergic selectivity of α-synuclein associated PD. 3.
The expressionless face (",masked facies,") is a sign of this disease. Strength and reflexes of the limbs, upper and lower, were normal. There was resistance to passive stretch in the opposing flexors and extensors upper extremities, i.e, "rigidity"; the presence of a noticeable concomitant tremor is described as "cogwheel" rigidity.
masked facies, (deadpan expression), and shuffling gait (festination) that are typically seen in PD. Postural instability As PD progresses, the patient develops characteristic postural and gait problems, usually standing with the head bent forward and walking with a propulsive gait, often walking with increasing speed and shuffling gait
Putaminal ,neurons, with D 2 receptors project through the globus pallidus external segment (GPe) ... Neurologists have called patients’ facial appearance a “stare” or “,masked facies,” (Latin, face or countenance), but now they usually describe the face as ,masked,.
This is a classic presentation for Parkinson’s disease, which is the most common cause of resting tremor. Parkinson’s disease frequently presents with a triad of resting tremor, bradykinesia, and cogwheel rigidity. This patient has the triad, as well as characteristic ,masked facies,, stooped posture, and …
Facial muscle rigidity can also partly or completely account for the ",masked facies,." The tremor of parkinsonism is a rhythmic (four to eight per second) oscillation of opposing muscle groups, which is particularly prominent in the distal portions of the extremities. The upper extremities are affected earlier than the lower extremities.
In a report of 242 patients who were exposed to CO, parkinsonism was diagnosed in 23 (9.5%) patients (46) The predominant features included ",masked facies,," short stepped gait, hypokinesia, rigidity, retropulsion, positive glabellar sign, grasp reflex, cognitive problems, and urinary and/or fecal incontinence; 43% patients had mutism.